Protein level predictions 7 - Aggregation prediction

|Aggregation of proteins have been linked with diseases like neurogenerative diseases. Missense mutations can change the properties of proteins so that its tendency to aggregate increase. For this reason the predisposition of mutated proteins is evalutated by using the tools described in this group.

 

 

Programs available

 

An extensive overview of tools predicting protein level changes can be found from the recent review  article by Thusberg and Vihinen. Click here to return to the main page of protein prediction tools.

 

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Description of programs

 

Aggrescan

website: Aggrescan
Reference:
 

ArchCandy

website: ArchCandy

Reference: Ahmed A.B., Znassi N., Ch√Ęteau M.T. and Kajava A.V. A structure-based approach to predict predisposition to amyloidosis. (2015) Alzheimers & Dementia 11(6):681-690
 

PASTA

website: PASTA
Download:
Reference:

 

TANGO

website: TANGO
Download:
Reference:

 

Waltz

website: Waltz
Download:
Reference:

 

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Useful databases

 

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Review articles

  • Janita Thusberg and Mauno Vihinen. Pathogenic or Not? And If So, Then How? Studying the Effects of Missense Mutations Using Bioinformatics Methods. Hum Mutat.2009 May;30(5):703-14: doi:10.1002/humu.20938

 

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Other articles

 

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Useful Links

 

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