Exome sequencing and the genetic basis of complex traits
|Originally posted:||28th May 2012: 11:00 pm|
|Last updated:||29th May 2012: 1:32 pm|
|Public - anyone can view|
Exome sequencing–based studies are emerging as a popular approach to test for association of rare coding variants with complex phenotypes. The promise of exome sequencing is grounded in theoretical population genetics and in the empirical successes of candidate gene sequencing studies. We discuss here several aspects of exome sequencing studies that we view as particularly important.