Computational tools for prioritizing candidate genes: boosting disease gene discovery
|Originally posted:||3rd July 2012: 9:54 am|
|Last updated:||18th July 2012: 9:40 am|
|Public - anyone can view|
Various studies (such as genetic linkage or 'omics'-based approaches) generate large lists of candidate genes, of which only a minority may be biologically relevant for a phenotype or disease of interest. This Review discusses computational tools for gene prioritization, emphasizing key considerations for how biologists can incorporate these tools into their research, and it includes hands-on tutorials.