The Long Path from QTL to Gene
|Originally posted:||20th September 2012: 9:00 pm|
|Last updated:||24th September 2012: 2:15 pm|
|Public - anyone can view|
by Norman R. Drinkwater, Michael N. Gould
The construction in the 1990s of high density genetic maps of the mouse and rat based on simple sequence length polymorphisms led to an explosion of activity directed toward the identification of quantitative trait loci (QTLs) that control a broad array of normal and abnormal biology. More than 3,900 mouse and nearly 1,000 rat QTLs have been mapped by linkage analysis in studies of, among others, behavior, bone morphogenesis, cardiovascular function, and metabolism, as well as diseases including arthritis, diabetes, and cancer.