Fast and accurate genotype imputation in genome-wide association studies through pre-phasing
|Originally posted:||23rd July 2012: 9:11 am|
|Last updated:||23rd July 2012: 9:11 am|
|Public - anyone can view|
Gonçalo Abecasis, Jonathan Marchini and colleagues report a pre-phasing strategy for genotype imputation in GWAS, which they show maintains accuracy while substantially lowering computational costs. Their approach has been implemented in both MACH and IMPUTE 2.0 software.