Older males beget more mutations
|Originally posted:||30th October 2012: 12:05 pm|
|Public - anyone can view|
Three papers characterizing human germline mutation rates bolster evidence for a relatively low rate of base substitution in modern humans and highlight a central role for paternal age in determining rates of mutation. These studies represent the advent of a transformation in our understanding of mutation rates and processes, which may ultimately have public health implications.