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Home » Groups » Functional Prediction

Protein level predictions 7 - Aggregation prediction

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Contributed by: Administrator
Originally posted: 6th October 2009: 9:49 am
Last updated: 12th February 2016: 2:38 pm
Short URL: https://gen2phen.org/node/7206
Interest group iconFunctional Prediction
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|Aggregation of proteins have been linked with diseases like neurogenerative diseases. Missense mutations can change the properties of proteins so that its tendency to aggregate increase. For this reason the predisposition of mutated proteins is evalutated by using the tools described in this group.

 

Contents
  • Programs available
  • Description of programs
  • Useful databases
  • Review articles
  • Other articles
  • Useful links

 

Programs available

 

  • Aggrescan
  • ArchCandy
  • PASTA
  • TANGO
  • Waltz

An extensive overview of tools predicting protein level changes can be found from the recent review  article by Thusberg and Vihinen. Click here to return to the main page of protein prediction tools.

 

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Description of programs

 

Aggrescan

website: Aggrescan
Reference:
 

ArchCandy

website: ArchCandy

Reference: Ahmed A.B., Znassi N., Château M.T. and Kajava A.V. A structure-based approach to predict predisposition to amyloidosis. (2015) Alzheimers & Dementia 11(6):681-690
 

PASTA

website: PASTA
Download:
Reference:

 

TANGO

website: TANGO
Download:
Reference:

 

Waltz

website: Waltz
Download:
Reference:

 

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Useful databases

 

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Review articles

  • Janita Thusberg and Mauno Vihinen. Pathogenic or Not? And If So, Then How? Studying the Effects of Missense Mutations Using Bioinformatics Methods. Hum Mutat.2009 May;30(5):703-14: doi:10.1002/humu.20938

 

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Other articles

 

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Useful Links

 

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‹ Protein level predictions 6 - Analysis of interatomic contacts up Protein level predictions 8 - Other tools predicting protein functional changes ›
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Prediction tools

  • Tools predicting protein level changes
    • Protein level predictions 1 - Pathogenic or not predictors
    • Protein level predictions 2 - Sequence alignment methods
    • Protein level predictions 3 - Conservation analysis
    • Protein level predictions 4 - Stability changes prediction
    • Protein level predictions 5 - Disorder prediction
    • Protein level predictions 6 - Analysis of interatomic contacts
    • Protein level predictions 7 - Aggregation prediction
    • Protein level predictions 8 - Other tools predicting protein functional changes
  • Tools considering epistatic effects
  • Tools predicting problems in mRNA splicing
  • Tools and methods for mapping genomic structural variation
  • Meta tools
  • Tools predicting the overal functional consequences of SNPs
  • SNP identification and annotation tools
  • Group home
  • Prediction Tools Wiki

Functional Prediction

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  • Functional Prediction
    • Group home
    • Prediction Tools Wiki
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