Protein level predictions 7 - Aggregation prediction
| Contributed by: | Administrator |
| Originally posted: | 6th October 2009: 9:49 am |
| Last updated: | 12th February 2016: 2:38 pm |
| Short URL: | https://gen2phen.org/node/7206 |
 Functional Prediction |
 Public - anyone can view |
|Aggregation of proteins have been linked with diseases like neurogenerative diseases. Missense mutations can change the properties of proteins so that its tendency to aggregate increase. For this reason the predisposition of mutated proteins is evalutated by using the tools described in this group.
Programs available
An extensive overview of tools predicting protein level changes can be found from the recent review article by Thusberg and Vihinen. Click here to return to the main page of protein prediction tools.
Description of programs
Aggrescan
website: Aggrescan
Reference:
ArchCandy
website: ArchCandy
Reference: Ahmed A.B., Znassi N., Château M.T. and Kajava A.V. A structure-based approach to predict predisposition to amyloidosis. (2015) Alzheimers & Dementia 11(6):681-690
PASTA
website: PASTA
Download:
Reference:
TANGO
website: TANGO
Download:
Reference:
Waltz
website: Waltz
Download:
Reference:
Useful databases
Review articles
- Janita Thusberg and Mauno Vihinen. Pathogenic or Not? And If So, Then How? Studying the Effects of Missense Mutations Using Bioinformatics Methods. Hum Mutat.2009 May;30(5):703-14: doi:10.1002/humu.20938
Other articles
Useful Links